Alternatives to chronic toxicity studies
Rolf Baß, Peter Grosdanoff, Toni Lehnert · Steinkopff eBooks · 1985
Testing for chronic toxicity plays an important role in the overall evaluation of the toxic potential of chemical substances. It is routinely performed in vivo, i.e. in whole rodent and nonrodent animals. Certain rules and regulations exist that govern the form of performance of chronic toxicity testing for different sectors of our chemical world, for example, OECD regulations for testing of chemicals, EEC and FDA regulations for testing pharmaceutical substances. The requirements differ in regard to the number and selection of species, number of animals per dose group and experiment, modes of application and duration of experiment.