Four top reasons why mutual information does not assess neural information processing

Don H. Johnson · Rice Research Repository (Rice University) · 2002

Mutual information between stimulus and response has been advocated as an information theoretic measure of a neural system's capability to process information. Once calculated, the result is a single number that supposedly captures the system's information characteristics over the range of stimulus conditions used to measure it. I show that mutual information is a flawed measure, the standard approach to measuring it has theoretical difficulties, and that relating capacity to information processing capability is quite complicated.

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