QSAR analysis of substituent effects on tambjamine anion transporters
Nicola Knight, Elsa Hernando, Cally J. E. Haynes, Nathalie Busschaert, Harriet J. Clarke, Koji Takimoto, María García‐Valverde, Jeremy Graham Frey, Roberto Quesada, Philip Alan Gale · Chemical Science · 2015
and the curvature of the parabolic dependence is a property of the membrane (and so similar for the different series of substituents) we found that for relatively simple substituents in certain locations on the tambjamine core, hydrophobic interactions clearly dominate, but for others, more specific interactions are present that change the position of the membrane hydrophobicity parabolic envelope.