QUANTITATIVE STRUCTURE - ACTIVITY RELATIONSHIP IN ANTIDIABETIC DRUGS BY USING TOPOLOGICAL DESCRIPTORS
Marcel Popescu, Alin Velea, Mihai Cioc, S. Tivadar · 2010
The quantitative structure – activity relationship in antidiabetic oral drugs has been analyzed on the basis of topological indices that allow to discriminate the structure of different molecules either small or large. The overall correlation structure – activity allows to find the best antidiabetic drugs and to predict the activity of new compound proposed as oral antidiabetic. The screened procedure based on topological indices prevents the expensive and long testing of a high number of compounds.