In Silico drug design and analysis of 4-Phenyl-4H-chromene derivatives as anticancer and anti-inflammatory agents
Nancy E. Thomas, Subin Mary Zachariah · International Journal of Pharmaceutical Sciences Review and Research · 2013
Cancer constitutes the second main mortality cause in the world. 4H-Chromene derivatives are an attractive template for the identification of potential anticancer agents. In recent years, there has been much interest in this class of compounds and their potential utility as anti-cancer drugs along with anti-inflammatory activity. An attempt has been made to control such life threatening diseases by synthesizing chromene based compounds. In this study we have computationally investigated the binding interaction of 4-phenyl-4H-chromene analogues with some known anticancer and anti-inflammatory targets (1TUB, 1UOM and 1TNR) by using ArgusLab and AutoDock programs. Nine of these ligands showed high docking scores than the unsubstituted 4Hchromene and exhibited better drug-likeliness parameters as compared to the reference drugs.