3D QSAR studies of Substituted Benzamides as Nonacidic Antiinflammatory Agents by kNN MFA Approach
Anupama Parate · 2014
A series of N- (4, 6 dimethyl-2-pyridinyl) benzamides as non acidic anti-inflammatory drugs was subjected to a 3D-quantitative structure activity relationship using kNN MFA approach. In the mentioned model it can be seen that the kNN MFA model obtained by using the stepwise variable selection method shows that electrostatic interactions (2 of 3 descriptors in SW are electrostatic field descriptors) plays major role in determining biological activity. It can also be noted that descriptor E_ 300 is implying the significant role of this electrostatic field interaction for structure activity relationship.