Quantitative Structure Activity Relationship Analysis of N Phenazine -1-carboxamides Analogs as Anti mycobacterial Agents
Arun Kumar Gupta, Ashvin R. Jaiswal, Sumit Prachnad · 2014
rd of the world’s population is already infected with TB. Every year, more than eight million new people develop active tuberculosis, and 2 million people die from TB. anti-tubercular agents, mole cular modeling analysis was performed to develop QSAR models that show substantial predictive promise for N-substituted p henazine activity with low standard error of estimation (0.2 22). Model (q 2 =0.600) and external predictivity ( r 2 pred tubercular activity is predominantly explained by t he topological descriptor (IC3) and empirical in design of inhibitors with enhanced potency.