Self-Organising Processes in the Immune System: Integration, Disintegration and Cluster Forming
Russian Federation, Rams Sb · 2013
Favorable patient outcomes depend on the individual's ability to adapt to the damaging factors of disease and to accept a therapeutic effect. The immune systems of patients with urgent surgical pathology are affected by multiple damaging factors, which lead to the formation of separate clusters with centres at points corresponding to the optimal characteristics of the immune system. The distance from the centre of the cluster is closely related to the patient disease severity. We examined 442 patients with urgent abdominal pathology. Using the numbers of CD3+, CD4+, CD8+ and CD16+ lymphocytes, we found six clusters of immune status. Lymphopenia was found across the series of clusters, from the first to the sixth. Adaptive loadings were measured by determining in each cluster the share of significant Spearman correlation coefficients (SCS) and correlation graphs (G). Moreover, we calculated the distance between the principal components obtained by factor analysis (S ) to determine individual adaptive loading. SCS and G levels increased from the first to the PC fourth clusters. The SCS and G reached critical values in the fourth cluster, after which it was reduced in the fifth and sixth clusters. S values highly correlated with SCS and G, but in opposite ways. This was coupled PC with increasing mortality in the fifth and sixth clusters. We believe that the observed features are the result of a failure in adaptation mechanisms and the emergence of distress in the fifth and sixth clusters. S values PC can be used for individual evaluation of the adaptive loading. abstract. Current rating adaptability due to the need for