A Prototype Intelligent Hybrid System for Hard Gelatin Capsule Formulation Development
Mintong Guo, Gunjan Kalra, Wendy I. Wilson, Yun Peng, Larry L. Augsburger · Pharmaceutical technology · 2002
ocietal pressures to reduce healthcare costs, coupled with the pharmaceutical industry’s need to maintain its economic incentive to develop new drugs, have required that the industry increase speed to market and reduce the number of failures and overall cost of new drug development. This need has made it imperative for the industry to use efficient, systematic approaches to both drug discovery and formulation design. To accelerate drug discovery, scientists now use highthroughput biological screens and combinatorial chemistry that lead to the rapid discovery and identification of numerous potentially useful drugs. Given this high rate of discovery, drug delivery system development for these drug substances—rather than drug discovery itself—is likely to be the rate-limiting step in getting new drugs to market.