COMPARITIVE IN-VITRO CYTOTOXICITY OF RED PIGMENT EXTRACT OF SERRATIA. MARCESCENS ON BREAST AND PROSTRATE CANCER CELL LINES
Maithili A. ATHAVALEa, Samir S. SOMAIYAa, Gayatri A. More, Sangeeta A. SRIVASTAVAa · 2013
The anticancer activity of the red-pigment extract of S.marcescens was evaluated on a panel of three breast cancer viz. MCF-7, MDAMB231 , T47D and three prostrate cancer viz. PC3, LNCaP and DU145 cell lines respectively by MTT assay. MTT assay showed an increase in the % viability of the tested cells against the decrease in concentration of the extract. IC50 of the extract was found to be 40.76, 110.53 and 113.81µg/ml for MCF-7, MDAMB231, T47D and 43.79, 37.66 and 23.64µg/ml for PC3, LNCaP and DU145 respectively. The activity of the extract was found to be almost similar for MCF-7 and PC3 but a very good activity on LNCaP and PC3 was obtained compared to that of MDAMB231 and T47D (p<0.05).Overall the study showed that the extract has a strong anticancer potential especially towards the prostrate cancer cells .