EFFECT OF IRON COMPLEXES WITH MANNICH TYPE LIGANDS ON VIABILITY OF TUMOUR CELL LINES
Radostina Alexandrova, Gergana Rashkova, Teodora Popova, Svetoslav Nanev Slavov, Nadia Stefanova, Otilia Costişor · 2005
The effect of three complexes of iron with Mannich type ligands were studied in vitro on animal and human tumour cells using neutral red uptake cytotoxicity assay. The following cell lines were used in the experiments - LSCC-SF- Mc29 (transplantable chicken hepatoma induced by the myelocytomatosis virus Mc29), LSR-SF-SR (transplantable sarcoma in rat induced by Rous sarcoma virus strain Schmidt-Ruppin), Hep2 (human hepatocellular adenocarcinoma), 8 MG-BA (human glioblastoma). On the basis of their cytotoxic activity the compounds investigated were grader as follows: Fe2(TAMEN)Cl6 > Fe2(BAMP)Cl4 > Fe2(BAMP)Cl6, Tested independently, both ligands were no or very low toxic at the concentrations examined.