Evaluation of Anticancer Potential of Bacolepsis nervosa decne. Ex. Moq. Against Ehrlich Ascites Carcinoma Induced Cancer in Swiss Albino Mice
Veerabahu Ramasamy Mohan · 2014
The present investigation was designed to determine the in vitro anticancer potential of the ethanol extract of Bacolepsis nervosa stem and leaves against Ehrlich Ascites Carcinoma (EAC) induced cancer in Swiss albino mice. The anticancer activity was evaluated using mean survival time, tumor volume and hematological studies. The ethanol extract of stem and leaves given orally to mice at the dose of 150 and 300 mg/kg body weight for 14 days. The high dose of B. nervosa stem and leaf extract (300 mg /kg) significantly reduced the tumor growth, increased life span of the mice and restoration of hematological parameters. The results suggest that the ethanol extract of B. nervosa exhibit significant antitumor effects in EAC bearing mice.