Synthesis and Molecular Docking Studies of 3-Benzylidene-8- Methoxy-6- (prop-1enyl) Chroman-4-One Based Compound against Different HIV Receptors
B. Saravanan, Akhilesh Upgade, Anusha Bhaskar, V. Manivannan · 2012
The Human Immunodeficiency Virus ( HIV) infection in human since last three decades is a tremendous issue in the area of infectious diseases. Currently plant based compounds are gaining more interest now-a-days in antiretroviral therpies. HIV replication is a target for the inhibition of HIV infection. The synthesized chroman-4-one based compound recognized as a antireplicative agent. With the synthesized crystals benzene and pyrone ring plays a major role ,molecular structure of the compounds were identified by subjecting the compound to X ray diffraction studies. Anti-HIV effects have been studied by different five viral Proteins. Ligand-protein molecular docking studies using advanced docking tools and minimum binding energies were computed. Comparison was made for better choice of protein ligand interaction