STUDY OF DYSLIPIDEMIA IN POSTMENOPAUSE WITH SPECIAL REFERENCE TO SERUM BUTYRYLCHOLINESTERASE AND LIPOPROTEIN (a) (Lp (a))
Suman Umeshchandra · 2012
Hyperlipidaemia is one of the important risk factor for the development of coronary heart disease. Butyrylcholinesterase is a serum esterase which is synthesized primarily in the liver, increased serum butyrylcholinesterase activity is found to be associated with altered lipid metabolism such as hyperlipoproteinemia, obesity and diabetes. Epidemiological studies have shown lipoprotein (a) is one of the independent risk factor for atherosclerosis. Postmenopausal women are known to have altered lipid profile; hence the present study is designed to estimate serum lipoprotein (a) [Lp(a)] and serum butyrylcholinesterase and to correlate with dyslipidaemia in post-menopausal women compared to pre-menopausal women. The study was conducted on 60 normal female volunteers with no history of liver disease, alcohol consumption, smoking, hypertension and diabetes, the volunteers were divided into premenopausal (n:30) and postmenopausal (n:30). Serum butyrylcholinesterase was determined on semiautomatic biochemical analyzer using commercial kit with butyryl-thiocholine as a substrate. Serum Lp(a) levels was estimated by a specific and sensitive immunoturbidometric assay. Concentration of serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL-C), high density lipoproteins (HDL-C) were determined on semi-automatic biochemical analyzer. There was significant increase in serum butyrylcholinesterase, TC, LDL-C, TG (P<0.01), Lp (a) levels (p<0.01) and significant decrease in HDL-C (P<0.01) in postmenopausal women. Serum TC, LDL-C, TG correlated positively with serum butyrylcholinesterase (p<0.01), Lp (a) (p<0.01) and negatively with HDL-C (P<0.01) in postmenopausal women. This suggests that dyslipidaemia associated with increase in serum Lp (a) and increase in pseudo cholinesterase and decrease in the HDL-C in post-menopausal women, possibly because of the estrogen deficiency associated with menopause.