3D-QSAR STUDIES OF MATRIX METALLOPROTEINASE-13 INHIBITORS
Annem Siva Reddy, Konda Ramadevi, Devarapalli Kezia, Meenakshi N. Rao, Madhu Malancha · 2009
A Three-dimensional quantitative structure-activity relationship models have been derived using molecule surface, electrostatic properties: positive and negative electrostatic fields, van der Waals effects and hydrophobic effects on a series of piperazine based analogs acting as matrix metalloproteinase-13 (MMP13) inhibitors. Correlation and regression analysis performed on these series of MMP-13 inhibitors .The results are critically discussed on the basis of Correlation matrix and significant regression Coefficients(R2=0.724). The obtained correlations also suggest that the presence of sulfonamide unit