Kallikreins (Psa) as New Molecular Marks in Early Diagnosis and Prognosis of Cancer
Motsakou Maria · Journal of Human Virology & Retrovirology · 2015
Although, this method is not perfect, but combines with Digital Rectal Examination (DRE) is better from others.The Positive Predictive Value (PPV) of PSA for values over 4ng/mL is 30-40%.A pathological mammography, for example has PPV 10-20% and it is more expensive than PSA screening test.The average annual growth of PSA is men with CaP or BPH is low (0.75 ng/mL/year for cancer and 0.1-0.5 ng/mL/year for BPH).So, as long as the amount of men that submitted to that screening test is higher year per year, the amount of men with PSA value over 4ng/mL moves closer to that limit.The PSA era will end when another special marker for this kind of screening test is more sensitive than PSA become available.