MDR against anticancer drugs- Review
Farzaneh Narimani, Leila Molavi · 2014
The resistance of tumors may occurs as a cross-resistance to a whole range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). Mechanisms of MDR: Non-cellular resistance mechanisms: Non-cellular drug resistance can arise as a consequence of in vivo tumor growth and typically associated with solid tumors. Poor tumor vascularization. The physiological properties of solid tumors that result deficiency in nutrients and oxygen. Cellular resistance mechanisms: