THE CORRELATION STUDIES OF ANTIMYCOBACTERIAL ACTIVITY FOR A NUMBER OF DERIVATIVES OF 4-CARBOXAMIDE
Emilia Amzoiu, Larisa Elisabeth Averis, Cornelia Bejenaru, Manuel Ovidiu Amzoiu, Paul Gabriel Anoaica · Annals of the University of Craiova - Agriculture Montanology Cadastre Series · 2014
In order to produce a desired physiological effect, substances have to cross cell membranes. The ability of a chemical compound to cross membranes is influenced primarily by the partition coefficient. This is a physical-chemical factor that directly influence the pharmacokinetic profile of the drug and indirect its pharmacodynamic profile. The paper is a QSAR study carried out on a class of substituted of carboxamide, having antimycobacterial activity against the atypical mycobacterial strains and that these compounds are inhibitors of the photosynthesis process. The purpose of such a study is to link the chemical structures of the compounds represented by a set of molecular descriptors with biological activity exhibited by them, expressed as IC50. Identifying these descriptors leads to information of the changes induced by the presence and nature of different chemical groups in the molecule, which allows optimization of analyzed biological activity.