Modelling a Bacteriums's Life: A Petri-Net Library in Modelica
Sabrina Proß, Bernhard Bachmann, Ralf Hofestädt, Karsten Niehaus, Rainer Ueckerdt, Frank‐Jörg Vorhölter, Petra Lutter · PUB – Publications at Bielefeld University (Bielefeld University) · 2009
For modeling biological systems the already existing Petri Net Libraries were further developed with OpenModelica using the SimForge graphical user interface (GUI). The Petri Nets elements were wrapped into models for different reaction types to simplify the modeling process. Additionally, a database connection was implemented for integrating kinetic data. The application of this new Reaction Library is demonstrated by the xanthan production of the bacterium Xanthomonas campestris pv. campestris. A mathematical model is introduced to predict growth and xanthan production, given an initial glucose concentration. The parameters of this model are estimated with the aid of the Optimization Toolbox in MATLAB.