Novel bivalent positive allosteric modulators of AMPA receptor
Mstislav Igorevich Lavrov, Владимир Викторович Григорьев, Сергей Олегович Бачурин, Vladimir A. Palyulin, N. S. Zefirov · Doklady Biochemistry and Biophysics · 2015
A positive allosteric modulator of AMPA receptors has been designed using computer-aided molecular modeling techniques. It possessed a record high experimentally confirmed potency in the picomolar concentration range and belongs to a new type of bivalent AMPA receptor ligands containing bicyclo[3.3.1]nonane scaffold. The suggested structure could serve as a basis for further optimization and development of drugs for the treatment of neurodegenerative diseases, cognition enhancement, and improvement of memory.