On the Existence of Identifiable Reparametrizations for Linear Compartment Models
Jasmijn A. Baaijens, Jan Draisma · SIAM Journal on Applied Mathematics · 2016
The parameters of a linear compartment model are usually estimated from experimental input-output data. A problem arises when infinitely many parameter values can yield the same result; such a model is called unidentifiable. In this case, one can search for an identifiable reparametrization of the model---a map which reduces the number of parameters such that the reduced model is identifiable. We study a specific class of models which are known to be unidentifiable. Using algebraic geometry and graph theory, we translate a criterion given by Meshkat and Sullivant for the existence of an identifiable scaling reparametrization to a new criterion based on the rank of a weighted adjacency matrix of a certain bipartite graph. This allows us to derive several new constructions to obtain graphs with an identifiable scaling reparametrization. Using these constructions, a large subclass of such graphs is obtained. Finally, we present a procedure for subdividing or deleting edges to ensure that a model has an identifiable scaling reparametrization.