Computer-aided diagnosis in breast MRI based on ICA and unsupervised clustering techniques
Anke Meyer‐Baese, Oliver Lange, Axel Wismüller, Gerda L. Leinsinger · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 2005
Exploratory data analysis techniques are applied to the segmentation of lesions in MRI mammography as a first step of a computer-aided diagnosis system. ICA and clustering techniques are tested on biomedical time-series representing breast MRI scans. This techniques enable the extraction of spatial and temporal features of dynamic MRI data stemming from patients with confirmed lesion diagnosis. By revealing regional properties of contrast-agent uptake characterized by subtle differences of signal amplitude and dynamics, these methods provide both a set of prototypical time-series and a corresponding set of cluster assignment maps which further provide a segmentation with regard to identification and regional subclassification of pathological breast tissue lesions.