SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
Anju Das Manikpuri, Sheela Joshi, Padmakar V. Khadikar · Journal of the Chilean Chemical Society · 2010
A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Grampositive and Gram-negative bacteria.The synthesized Mannich bases were characterized by elemental and spectral analysis.The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing 1 H NMR chemical shift, physicochemical properties and topological indices as the correlating parameters.Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.