Improvement of Citalopram Purity by Adsorption on Zeolite Solid Phase
M Salehparhizkar, Seyed Vahid Shetab Boushehri, E Amirhosseini · 2010
Introduction: Citalopram Hydro bromide is one of the antidepressant medications that belongs to the family which are the Selective inhibitors of serotonin reuptake . Due to having minimal side effects this medication is now under a huge consideration from psychiatrics and also patients. Citalopram Hyrobromide is among the most important salt that are produced from Citalopram and its high degree of purity will cause more effectiveness and less side effects. Aim: to reach to a final product -citalopram hydrobromide - with 99% purity by using activated natural Zeolite named clinoptilolite as an adsorptive solid phase for citalopram and elimination of its impurities. Method: In this method produced Citalopram is solved in an Acid and then it is purified by adding Clinoptilolite that is an activated Zeolite then citalopram will be extracted , and finally its bromide salt has been prepared in a solvent . The product purity is being measured with high performance liquid chromatography (HPLC) device. Results and discussion: the results of experiments have been inspected before adding Zeolite and after that. The results showed that adding Zeolite cause the degree purity to by increased from 93.75 to 99.45 and total amount of impurities decreased from 0.25 % to 0.064%. Other properties of product are in complete agreement with the standards of pharmacopeia of America. Conclusion: Analysis shows that in this method the degree of purity is increased and the amount of impurities is decreased. Besides the most important advantage of this method is that less amount of solvent is consumed