Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates
Carolina D. Duarte, Eliezer J. Barreiro, Carlos Alberto Manssour Fraga · Mini-Reviews in Medicinal Chemistry · 2007
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures. Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives