A CNN algorithm for real time analysis of DNA microarrays
Paolo Arena, Luigi Fortuna, Luigi G. Occhipinti · IEEE Transactions on Circuits and Systems I Fundamental Theory and Applications · 2002
The work focuses on a new approach for DNA-chip image processing by using the cellular neural network (CNN) paradigm. In particular, the work aims to solve the main issues in automatic classification and spot validation that arise during an automatic DNA microarray analysis procedure. This contribution briefly presents the basic DNA micro-array technique and the state-of-the-art technologies, and introduces the idea of processing DNA chip data via CNNs, reporting suitable examples. The algorithm described has been developed using a high level language, dedicated to CNN universal machine (CNNUM) chip programming, and validated on a typical fluorescence image from a DNA microarray after hybridization.