Mapping uniquely occurring short sequences derived from high throughput technologies to a reference genome
Pavlos Antoniou, Jacqueline W. Daykin, Costas S. Iliopoulos, Derrick Kourie, Laurent Mouchard, Solon P. Pissis · 2009
Novel high throughput sequencing technology methods have redefined the way genome sequencing is performed. They are able to produce tens of millions of short sequences (reads) in a single experiment and with a much lower cost than previous sequencing methods. Due to this massive amount of data generated by the above systems, efficient algorithms for mapping short sequences to a reference genome are in great demand. In this paper, we present a practical algorithm for addressing the problem of efficiently mapping uniquely occuring short reads to a reference genome. This requires the classification of these short reads into unique and duplicate matches. In particular, we define and solve the Massive Exact Unique Pattern Matching problem in genomes.