ADME Properties of Drugs
Li Di, Edward H. Kerns · Wiley Encyclopedia of Chemical Biology · 2008
Abstract ADME properties have tremendous impact on the success of drug candidates. They are a set of fundamental physico‐chemical and biochemical properties of drug molecules that can be affected by physiologic conditionsin vivo: solubility, permeability, stability, metabolism, and others. ADME properties can be improved through structural modification by medicinal chemists. They are important bothin vitroandin vivo. A successful drug must possess a balance of good potency and drug‐like properties. High‐throughput ADME assays have been developed and implemented widely in the pharmaceutical industry to reduce the attrition of drug candidates. The data are used to identify potential liabilities, guide structural modification, prioritize lead series, select compounds forin vivostudies, and diagnosein vivoassay results. Studies have demonstrated that early screening of ADME properties is a successful approach to enhance the quality of drug candidates.