Prognostic Significance of Amoeboid Movement Configuration in Lymphoid Cells from Children with Acute Lymphoblastic Leukaemia
Ulf Sjögren, Stanislaw Garwicz · Scandinavian Journal of Haematology · 1980
Bone marrow smears from 72 consecutive children with a recent diagnosis of acute lymphoblastic leukaemia (ALL) have been morphologically analyzed. A high incidence of lymphoid cells with amoeboid movement configuration (AMC) seems to indicate a more favorable prognosis independently of other prognostic factors e.g. age, WBC or sex. A positive correlation between the AMC and the mitotic indices (MI) of the lymphoblasts indicates some connection between the motility and the proliferative activity of the leukaemic cell clone.