Interactions of Polyphenols with the P450 System: Possible Implications on Human Therapeutics
M. José Gómez‐Lechón, Idania Rodeiro, María Teresa Donato, Agustín Lahoz, Gabino Garrido, René Delgado · Mini-Reviews in Medicinal Chemistry · 2008
Polyphenols are a family of natural compounds with many biological properties. This review focuses on their potential interaction on the cytochrome P450 system. Effects of phenolic acids, anthocyanins, stilbenes, catechins and other flavonoids on the drug metabolising function are revised. Their daily intake and presence in herbal medicines justify the study of potential drug-interaction to prevent undesirable clinical consequences.