QSAR Investigation of New Cognition Enhancers
John C. Dearden, Mark Hewitt, Athina A. Geronikaki, Taissia L. Garibova, Fliur Macaev, Татьяна Александровна Воронина · QSAR & Combinatorial Science · 2009
Abstract Increasing longevity means that there is an increased likelihood of loss of cognitive functions and of incidence of dementias. There is thus a greater demand for cognition‐enhancing (noötropic) drugs. Some such drugs are already available, but many display serious side‐effects. We have designed, synthesized and tested a number of novel chemical entities that are predicted by the PASS software to be potential noötropic agents. The results have been subjected to QSAR (quantitative structure–activity relationship) analysis, and good QSAR correlations, with external validation, have been obtained, which can be used predictively to guide design of additional potential cognition‐enhancers.