How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
Di Ianni, Mauricio Emiliano, Talevi, Alan · Molecular & Cellular Epilepsy · 2014
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.