Robust applications in time-shared distributed systems
A.M. Dobber · Centrum Wiskunde & Informatica (CWI), the national research institute for mathematics and computer science in the Netherlands · 2006
In chapter 3 a new approach to dihydropyrimidines C will be discussed.The scope and limitations of a new four-component reaction have been explored resulting in dihydropyrimidines, phosphoramidates and triazinane diones.Chapter 4 is an extension of chapter 3.Here the synthesis of thiazines using a similar four component approach and a subsequent rearrangement to the corresponding dihydropyrimidine-2-thiones is described.Chapter 5 discusses a mild chemo-enzymatic oxidation-hydrocyanation protocol for the synthesis of cyanohydrins.These cyanohydrins are precursors for the 3'-deoxyribose moiety (B).In chapter 6 the synthesis of such a 3'-deoxyribose moiety B will be discussed.Both a chemical and chemo-enzymatic route are described.Chapter 7 summarises the synthetic studies towards mureidomycin A and dihydropyrimidine nucleosides A. The synthesis of the several building blocks of the peptide backbone will be discussed.In addition a model study is described about the coupling of dihydropyrimidines to ribose sugars. 1.8 Biologically Active Nucleoside Analogues with 5-or 6-Membered Monocyclic NucleobasesA large range of nucleoside analogues is known with a wide variety of therapeutic actions.In this chapter we discuss nucleoside analogues with a 5-or 6-membered monocyclic nucleobase, not having the core heterocyclic skeleton of a natural nucleobase and being attached to a 5-ring sugar (ribose) via a nitrogen atom.