ReportednandDqvalues can be misleading
Louis Zeitz · British Journal of Radiology · 1979
Some of the uncertainties in applying survival curves from tissue-culture studies to the prediction of survival probabilities for the treatment of malignant melanoma have been reported previously (Zeitz and McDonald, 1978). An additional uncertainty, which would apply in general in the application of in vitro single-cell survival curves in making probability estimates for tumour cell survival with fractionated doses, can be understood from the consideration of two survival curves for Harding-Passey mouse melanoma. Figure 1 shows data originally obtained by Dewey (1971) and later by Dewey and Field (1975) with cells repeatedly subcultured from the same cell line.