New Way for the Preparation of 4-Phenyl-2-oxobutyric Acid Ethyl Ester
V. A. Slavinska, Dz. Sile, É. Kh. Korchagova, M. Yu. Katkevich, Edmunds Lukevics · Synthetic Communications · 1996
New way for the preparation of 4-phenyl-2-oxobutyric acid ethyl ester 1 has been elaborated. The four-steps synthesis from ethyl pyruvate involves the consecutive condensation of ethyl pyruvate with benzaldehyde, hydrogenation of benzylidenepyruvic acid sodium salt 2a to 4-phenyl-2-hydroxybutyric acid 3 on Ni catalysts, esterification of 3 and oxidation of the ester to 1 with CrO3.