Virtual Screening Strategies: A State of Art to Combat with Multiple Drug Resistance Strains
Asad Ullah Khan · MOJ Proteomics & Bioinformatics · 2015
Introduction:The resistance among the bacterial world has been increasing against majority of antibiotics.An effective approach to combat with this situation is the use of potential inhibitors with proper combination of these antibiotics.Traditionally, high throughput screening is used to screen the potential drug for the selected target.However, this strategy is costly and time consuming.Approaches: Thus, an alternative method is required for facilitating the optimal leads in early drug discovery process.Virtual screening strategies have also been successfully applied during the past decades in screening large chemical libraries with aim to identify the potential bioactive hits.Such techniques are cost-effective and reliable that can be applied to identify potential leads with improved hits rates. Conclusion:In the present review, we have described some of the computational techniques that can be use for designing potential drug candidates against the multiple drug resistant strains.At the end some of the recent successful studies were also discussed.