Registration of Multiple Medical Images Using N-dimensional Mutual Information
Changquan Ren, Qing Liu, Yanhong Zhou, Shenyang Xu · 2008
The medical image registration has been all confined in registering two images and rarely involved multiple images (three and more than three). Using the expanded mutual information measure (E-MIM) to register multiple images, which is inefficiency, can't meet the clinical requirement, and mutual information (MI) values are not necessarily nonnegative. In this paper, we introduce an N-dimensional mutual information measure (N-MIM), which can ensure MI values are nonnegative, bounded to range from 1 to 2. At the same time, the rate of the registration has moved up. Then this definition is tested and proved to be effective on registration of multiple lumbar vertebra images through simulation.