Biochemical and Metabolic Modeling and Simulation with Modelica
Emma Larsdotter Nilsson, Peter Fritzson · 2005
In the drug industry, the later a substance is dis-charged from the drug development pipeline, the higher the financial cost. In order to reduce the num-ber of lead compounds a number of computerized sys-tems have been suggested, and in most of these systems modeling and simulation of the lead compound’s ef-fects on different metabolic pathways are essential. In these systems, substances that are expected to be harm-ful or lethal can be removed at an early stage and a reduced number of lead compounds can be chosen for the concluding tests. Given Modelica’s previous success with modeling and simulation of huge and complex systems it is likely that it will also be suitable for modeling, simulation, and visualization of metabolic pathway systems, e.g., those systems used in the drug industry. A Modelica li-brary designed to be used for modeling, simulation, and visualization of metabolic pathways is the special-Modelica library BioChem.