Differential effects of atorvastatin, pravastatin, rosuvastatin and simvastatin on lungs from mice exposed to cigarette smoke
Samuel Santos Valença, Thiago Ferreira, Alan Aguiar Lopes, Denise Cardoso, Karla Maria Pereira Pires, Larissa Silva-Neto, Manuella Lanzetti, Jackson Nogueira Alves, Eduardo Tavares Lima Trajano, Renata Tiscoski Nesi, Marina Valente Barroso, Romulo Pinto, Claudia Farias Benjamim, Luis Crsitovao Porto · European Respiratory Journal · 2012
Short-term cigarette smoke (CS) exposure leads to acute lung inflammation through its influence on oxidants/antioxidants imbalance, but lately statins have shows anti-inflammatory and antioxidant effects. Therefore, we aimed analyzing the effects of four different statins on the lungs of mice exposed CS. Male C57Bl/6 mice were divided into six groups (n=8 each): Mice exposed to the smoke from 12 cigarettes/day/5 days (CS group); exposed to smoke from 12 cigarettes per day for 5 days plus atorvastatin (10 mg/kg/day; CS+A group), or pravastatin (5 mg/kg/day; CS+P group), or rousovastatin (5 mg/kg/day; CS+R group) or sinvastatin (20 mg/kg/day; CS+S group); control group was sham-smoked. One day after the last CS exposure, mice were sacrificed, the bronchoalveolar lavage fluid (BAL) was performed and the lungs were removed for histological analysis and homogenized for biochemical analyses. Oxidant levels were reduced in CS+S (p