Clustering mass spectrometry data using order statistics
Douglas J. Slotta, Lenwood S. Heath, Naren Ramakrishnan, Richard F. Helm, Malcolm Potts · PROTEOMICS · 2003
Mass spectrometry data is inherently uncertain. Rather than compare peak heights across samples, a comparison can be made of the relative ordering of the peak height across samples. Order statistics are used to provide a distance metric between each ordered list of peak heights from the samples. A principal component analysis is performed on the set of distance vectors to highlight to important components.