AIDS viral DNA amplification by polymerase chain reaction employing primers selected by AI expert system and an ART neural network
D. Benachenhou, Masud Cader, Harold H Szu, Larry Medsker, Carl T. Wittwer, D. Garling · 2002
To diagnose AIDS patients, doctors are starting to use the methodology of amplification induced by thermal annealing and by adding specific primers to imitate the polymerase chain reaction of the denatured DNA mutated by several types of human immunodeficiency viruses. An adaptive resonance theory (ART) neural network working in concert with an artificial intelligence (AI) rule-based system is shown to be efficient for enhancing the choice of the needed good primers. Because of the tradeoff between the simplicity of primers and the specifics of primers, doctors prefer to diagnose different viral types by administering patients with different sets of good primers. Thus, AI provides ART with both the background for self-organization and the foreground for the final goal.>