The narcotic discriminative stimulus complex: relation to analgesic activity
Françis C. Colpaert, Carlos J. E. Niemegeers, Paul A. J. Janssen · Journal of Pharmacy and Pharmacology · 1976
The ability of drugs to produce the narcotic discriminative stimulus complex is found to be highly correlated with their analgesic activity; in contrast, no relation with their antidiarrhoeal activity is evident. The findings suggest that the narcotic discriminative stimulus complex is a centrally mediated effect of narcotic drugs.