Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery
Robert Shoemaker, Dominic A. Scudiero, Giovanni Melillo, Michael J. Currens, Anne P. Monks, Alfred A. Rabow, David G. Covell, Edward A. Sausville · Current Topics in Medicinal Chemistry · 2002
Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology, "rational" drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.