2D-QSAR Studies of Substituted Pyrazolone Derivatives as Anti-Inflammatory Agents
Rishikesh V. Antre · Medicinal Chemistry · 2012
A QSAR study was performed on a series of substituted pyrazolone derivatives.The compounds in the selected series were characterized by spatial, molecular and electrotopological descriptors using QSAR module of molecular design suite (V-Life MDS 4.0).In present research paper we reported 2D-QSAR studies of substituted pyrazolone derivatives.Correlations between inhibitory activities and calculated predictor variables were established through partial least square regression (stepwise forward) method.