Antioxidative Actions of Statins: Potential Mechanisms for Antiathersclerotic Effects
Takanori Watanabe, Kenichi Yasunari, Munehoro Nakamura · Mini-Reviews in Medicinal Chemistry · 2006
Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo. Keywords: Statins, oxidative stress, atherosclerosis, carotid artery, leukocytes, flow cytemetory