Synthesis of 4‐Alkylpyrazoles as Inhibitors of Liver Alcohol Dehydrogenase
Aurea Echevarrı́a, Manuel Martín‐Pastor, Concepción Pérez, Isabel Rozas · Archiv der Pharmazie · 1994
Theoretical studies by shape analysis of the molecular electrostatic potential on the van der Waals surfaces of a set of 4-alkylpyrazoles predicted 4-isopentyl derivative as a good inhibitor of liver alcohol dehydrogenase. Thus, the new 4-isopentyl and the already known 4-octylpyrazole have been prepared by a novel route. The isopentyl derivative has been tested as inhibitor of horse liver alcohol dehydrogenase giving the result predicted by the theoretical studies.