A Systems Biology Approach to Personalizing Therapeutic Combinations
Lawrence N. Kwong, Timothy Paul Heffernan, Lynda Chin · Cancer Discovery · 2013
The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.