Multifunctionality of Drug’s Pharmacophores within an Organism
Toshihiko Tashima · Drug Designing Open Access · 2014
By definition of term, it is thought that drug’s pharmacophores function only to have within an organism.pharmacophores also possess pharmacokinetic aspects such as absorption, distribution, metabolism, excretion, and toxicity (ADMET). Thus, it is important to include pharmacokinetically advantageous elements in drug design. Both chemical knowledge and biological knowledge are needed for such drug design. In this short review, multifunctionality of drug’s pharmacophores is described with three examples (pravastatin, penicillin, and enalapril).