Structural and Toxic Mechanism‐Based Approaches to Designing Safer Chemicals
Stephen C. DeVito · 2012
Abstract The sections in this article are Toxicophores Electrophilic Toxicophores Designing Safer Electrophilic Substances Structure–Activity Relationships Aliphatic Carboxylic Acids Organonitriles Quantitative Structure–Activity Relationships (QSARs) Isosteric Substitution as a Strategy for the Design of Safer Chemicals Isosteric Substitution in the Design of Safer Drug Substances Isosteric Substitution in the Design of Safer Pesticides Isosteric Substitution in the Design of Safer Commercial Chemicals Conclusion Disclaimer