The acceptance of in silicomodels for REACH: Requirements, barriers, and perspectives
Emilio Benfenati, Rodolfo Gonella Diaza, Antonio Cassano, Simon Pardoe, Giuseppina C. Gini, Claire Mays, Ralf Knauf, Ludger Benighaus · Chemistry Central Journal · 2011
In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes.